Nonenzymatic Amperometric Aptamer Cytosensor for Ultrasensitive Detection of Circulating Tumor Cells and Dynamic Evaluation of Cell Surface N-Glycan Expression
By Liu, Jin-Xia; Bao, Ning; Luo, Xiliang; Ding, Shou-Nian
Published in ACS Omega
2018
Abstract
Dynamic assessment of glycan expression on the cell surface and accurate determination of circulating tumor cells are increasingly imperative for cancer diagnosis and therapeutics. Herein, a unique and versatile nonenzymatic sandwich-structured electrochemical cytosensor was developed. The cytosensor was constructed based on a cell-specific aptamer, the lectin-functionalized porous core